Morphofunctional state of the rat’s liver under the influence of Aralia elata alcohol tincture during the high-fat diet

Aralia tincture (Aralia elata) is a well-known adaptogen, so most of its effects that influence the body are associated with general properties this plant's preparations. They metabolic regulators increase body's ability to adapt various environmental stressors and prevent occurring damage. The purpose work determine effect doses A. elata roots alcohol on liver morphofunctional state laboratory rats receiving diet excess fat. From 28 young consumed an fat for 35 days, four groups were formed. Animals first group (control) received pure water without restriction; second – 0.1 % ethanol, third fourth 0.01 (A. elata), respectively. After experiment's completion, absolute relative mass histostructure animals determined, biochemical blood tests performed main indicators organ's functional activity. In kept diet, replacement ethanol solution aralia caused decrease in liver, significant increase. It has been demonstrated causes total protein level blood. An analysis enzyme activity shown consumption reduced AST ALT from value control group, returned these group. was characterized by appearance signs fatty degeneration along periphery hepatic lobules, addition accumulation droplets detected both perilobular (around lobules) zone center lobule itself near central vein. hepatocytes located mainly large drops have accumulated, small ones. use tinctures improved parenchyma's morphological state. Fatty less pronounced. Fat inclusions cytoplasm small, diffusely cytoplasm, did not show cell destruction.